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Subproject MRI
Quantification of Functional and Biophysical Information in Magnetic Resonance Imaging
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Keywords: microenvironment properties, optimized parallel imaging, principal and independent component analysis, molecular imaging
Information: The aim of this project is the development and implementation of dedicated
mathematical methods for improved quantification of biophysical and physiological parameters in
magnetic resonance imaging. These parameters play a pivotal role for structural and functional
analysis and will also be used as surrogate biomarkers. The extraction and quantification of functional
information from MR-images is typically based on the application of sophisticated mathematical methods.
In the whole field, many of the mathematical challenges refer to inverse or optimization problems.
Challenges in functional MRI include further improvements in spatial and temporal resolution, inhomogeneous
RF-field and coil sensitivities, physiological motion, or static field inhomogeneities induced
by susceptibility variation in the body. In the short-term perspective of this proposal it is intended to
improve image reconstruction with nonlinear inversion for faster imaging through parallel sampled and
optimally encoded data and the integration of parameter estimation and artifact correction within the
reconstruction process. Fast parallel implementation of algorithms, specific pharmacokinetic modeling,
feasibility studies and application of the improved algorithms will be performed with additional personal
of the institute or in cooperation with other projects. In the long-term perspective there is the vision of
a completely new MR procedure based on integrated image reconstruction, parameter estimation and
artifact suppression.
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