Seminar on Optimization and Control in Physiological Systems (in Englisch, für Naturwissenschaftler und Mediziner)

course number 621.140 winter 2001-02
Course on Optimization and Control in Physiological Systems

(for Mathematicians and Life Scientists)

(2 hours of course credit)

F. Kappel¹, T. Kenner², D. Schneditz², J. Batzel¹, R. Pilgram², D. Auerbach², M. Bachar¹,
M. Fink¹

1Department of Mathematics, ²Department of Physiology, Karl-Franzens University, Graz, Austria

Purpose

In this course we will examine some important concepts and systems in human physiology, both from the perspective of the physiologist and the mathematician. As an end result of this seminar it is hoped that both the physiologist's and the mathematician's perspective will complement each other and advance joint knowledge.

The inspiration for the course stems from a joint Physiology and Mathematics working seminar within the Cardiovascular Respiratory Control Group of the Special Research Center for Optimization and Control at the University of Graz (Spezialforschungsbereich F-003) sponsored by the Austrian Science Fund.

The web page for this course can be found from the KFUG Mathematics web page or at:

http://bedvgm.kfunigraz.ac.at:8001/jerry/ws01_seminar/home.html

Organization

We will meet on Tuesdays from 16.00 to 17:30 in the Seminarraum 11.32 of the Department of Mathematics, Heinrichstrasse 36, third floor.

Ten lectures will be given jointly by a physiologist and a mathematician as well as two computer labs to experiment with cardiovascular models implemented in MatLab.

Handouts on presented topics and examples will be made available during the course. Please, provide your e-mail address.

Students wishing credit for this course will be formed into groups and asked to present a 30 minute report on a recently published research paper using the concepts and skills developed in the course.

The course will rely extensively on the text "Physiological Control Systems; Analysis, Simulation, and Estimation" by M. C. K. Khoo, IEEE Press, 2000

Topics, Times & Lecturers

Planning meeting (Oct. 2)

Basic Topics

Introduction to modeling (Oct.9, all organizers)

Development of a lung mechanics model; steady state analysis (Oct.23, Auerbach & Batzel)

Development of a muscle control model; dynamic analysis (Oct. 30, Pilgram & Fink)

1^st Lab on models discussed above (Nov. 6, Auerbach, Batzel, Pilgram & Fink)

Advanced circulatory control model; frequency analysis (Nov. 13, Schneditz & Bachar)

2^nd Lab on circulatory control model (Nov. 20, Schneditz & Bachar)

Advanced Topics

Modeling of the respiratory control system, 2 lectures ( & Nov. 27 & Dec. 4, Batzel & Auerbach)

Modeling the insulin-glucose system, 2 lectures ( & Dec. 11 & Jan. 8, Bachar & Schneditz)

Modeling the baroreflex control system, 2 lectures (Jan. 15 & 22 & Fink & Pilgram)