Seminar on Optimization and Control in Physiological Systems (in Englisch, für Naturwissenschaftler und Mediziner)

Summer Semester 2003 - Course Number 621.140
Seminar on Optimization and Control in Physiological Systems

(for Mathematicians and Life Scientists)

(2 hours of course credit)

F. Kappel¹, T. Kenner², D. Schneditz², J. Batzel¹, D. Auerbach², M. Bachar¹,
M. Fink¹

1Department of Mathematics, ²Department of Physiology, Karl-Franzens University, Graz, Austria

Purpose

In this course we will examine some important concepts and systems in human physiology, both from the perspective of the physiologist and the mathematician. As an end result of this seminar it is hoped that both the physiologist's and the mathematician's perspective will complement each other and advance joint knowledge.

The inspiration for the course stems from a joint Physiology and Mathematics working seminar within the Cardiovascular Respiratory Control Group of the Special Research Center for Optimization and Control at the University of Graz (Spezialforschungsbereich F-003) sponsored by the Austrian Science Fund.

The web page for this course can be found from the KFUG Mathematics web page or at:

http://www-ang.kfunigraz.ac.at/~batzel/ss03_seminar/index.html

Organization

We will meet on Tuesdays from 15.00 to 16:30 in the Seminarraum 11.32 of the Department of Mathematics, Heinrichstrasse 36, third floor.

Ten lectures will be given jointly by a physiologist and a mathematician as well as two computer labs to experiment with physiological models implemented in MatLab. Basic concepts of control theory, modeling, and simulation with matlab and Simulink will be presented as well as discussion of current research of the instructors and topics of current research interest in medical applications. Special lectures from visitng reasearchers will also be given.

Handouts on presented topics and examples will be made available during the course. Please, provide your e-mail address.

Students wishing credit for this course will be formed into groups and asked to present a 30 minute report on a recently published research paper using the concepts and skills developed in the course.

The course will use the text "Physiological Control Systems; Analysis, Simulation, and Estimation" by M. C. K. Khoo, IEEE Press, 2000

Topics

Planning meeting (March 11)

Basic Topics

Introduction to matlab

Basic issues in modeling physiological systems

Development of a cardiovascular model for orthostatic blood pressure control

Modeling a dialysis process to substitute for liver function

Advanced circulatory control model

Kidney dialysis and volume and pressure control

Advanced Topics

Modeling insulin control of glucose 2 lectures with guest researcher

Modeling the baroreflex control system, 2 lectures